Mechanism of receptor mediated direct penetration
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Cell entry mechanisms of HSV: what we have learned in recent years
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
During viral infection the first challenge that viruses have to overcome is gaining access to the intracellular compartment. The infection process starts when the virus contacts the surface of the host cell. A complex series of events ensues, including diffusion at the host cell membrane surface, binding to receptors, signaling, internalization, and delivery of the genetic information. The focus of this review is on the very initial steps of virus entry, from receptor binding to particle uptake into the host cell. We will discuss how viruses find their receptor, move to sub-membranous regions permissive for entry, and how they hijack the receptor-mediated signaling pathway to promote their internalization. Viruses are strict intracellular parasites and their life cycle is fully reliant on hijacking cellular functions to promote their replication and spread.
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Rosenkranz 1,2 , A. Ulasov 1,3 , T. Slastnikova 1 , Y. Khramtsov 1 , and A.
Metrics details. Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire process is dictated by events occurring at multiple time and length scales.
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